Product Name: Lapatinib
Cas No.: 231277-92-2
Information: EGFR/HER2 inhibitor,potent,selective and reversible
Other Names: Tykerb;GW572016;GW-572016;GW 572016, Lapatinib tosilate hydrate
Chemical Name: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
Canonical SMILES: CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
MF: C29H26ClFN4O4S
MW: 581.0575
Purity: 98% by HPLC,
Boiling point: 750.737°C at 760 mmHg
Flash point: 407.831°C
Color: White Powder
Model Number: API-Lapatinib
Type: Antineoplastic Agents
Grade Standard: Medicine Grade
Solubility: Soluble in DMSO > 10 mM
Storage: Store at -20°C
General tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition: Evaluation sample solution : ship with blue ice. All other available size: ship with RT , or blue ice upon request
Background: Lapatinib (also known as GW572016), a member of the 4-anilinoquinazoline class of kinase inhibitors, is a potent, reversible and selective small-molecule inhibitor of both epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2) tyrosine kinases that inhibits recombinant EGFR and HER-2 tyrosine kinases in cell-free biochemical kinase assays with values of 50% inhibition concentration IC50 of 10.8 nmol/L and 9.3 nmol/L respectively. Lapatinib interferes with the adenosine triphosphate binding in the tyrosine kinases domains of both EGFR and HER-2 resulting in the inhibition of auto-phosphorylation and resultant downstream signaling activities (such as cellular proliferation and survival).
Brand Name: Huavet
Place of Origin: Shaanxi, China (Mainland)
USAGE: Pharmaceutical Intermediates
Inventory status: in stock
Shelf life: 2 years
Sample: Available
COA (Certificate of Analysis): Available
MSDS (Material Safety Data Sheet): Available
HPLC Spectrum: Available
ISO: Approved
GC: Available
NMR (Nuclear Magnetic Resonance): Available
Packaging Details:1g,5g,10g,50g,100g/bottle, 1kg/tin for trial order,25kg/drum for commercial quantity. Specific packing required by customer
Delivery Detail: Prompt shipment
