Product Name: Apremilast
CAS No.:608141-41-9
Information: PDE4 inhibitor
Description: Apremilast (CC10004) is a novel small-molecule inhibitor of PDE4 with an IC50 value of 74 nM.
Chemical Name: N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide
Canonical SMILES: CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
Other Names: CC-10004
MF: C22H24N2O7S
MW: 460.500214
Purity: 99%
Loss on Drying: ≤5.0%
Ash: ≤5.0%
Appearance: White powder
Type: Treatment of psoriatic arthritis Agents
Grade Standard: Medicine Grade
Model Number: API- Apremilast
Solubility: Soluble in DMSO > 10 mM
Storage: Store at -20°C
General tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition: Evaluation sample solution: ship with blue ice. All other available size: ship with RT , or blue ice upon request
Background: Apremilast, also known as CC-10004, is a novel and potent small-molecule inhibitor of phosphodiesterase 4 (PDE4), a key enzyme involved in cyclic adenosine monophosphate (cAMP) degradation and cytokine production of inflammatory cells. Apremilast binds to the catalytic site of PDE4, with values of inhibition constant IC50 and affinity constant Kiof 0.074 μM and 68 nM respectively, consequently leading to the degradation of cAMP. Apremilast exhibits anti-inflammatory activities against inflammatory disease in animal models as well as human chronic inflammatory diseases (such as psoriasis and psoriatic arthritis) by blocking the synthesis of a range of pro-flammatory cytokines and chemokines, including tumor necrosis factor alpha, interleukin 23, CXCL9 and CXCL10.
Brand Name: Huavet
Place of Origin: Shaanxi, China (Mainland)
Usage: Pharmaceutical Intermediates
Inventory status: in stock
Shelf life: 2 years
Sample: Available
COA (Certificate Of Analysis): Available
MSDS (Material Safety Data Sheet): Available
HPLC Spectrum: Available
ISO: Approved
GC: Available
NMR (Nuclear Magnetic Resonance): Available
Packaging Details: 1g,5g,10g,50g,100g/bottle, 1kg/tin for trial order,25kg/drum for commercial quantity. Specific packing required by customer
Delivery Detail: Prompt shipment
