Product Name: Alogliptin Benzoate
CAS No.: 850649-62-6
Information: DPP-4 inhibitor,potent and highly selective
Description Alogliptin benzoate (SYR 322) is a potent, selective inhibitor of DPP-4 with an IC50 value of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.
Other Names: SYR322, SYR-322, Nesina;
Chemical Name: 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile;benzoic acid
Canonical SMILES: CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N.C1=CC=C(C=C1)C(=O)O
Solubility: Soluble in DMSO
Storage: Store at -20°C
General tips: For obtaining a higher solubility , please warm the tube at 37℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition: Evaluation sample solution : ship with blue ice. All other available size: ship with RT, or blue ice upon request
Background: Alogliptin is a novel, highly selective and potent inhibitor of serine protease dipeptidylpeptidase-4 (DPP-4) with IC50 value of less than 10 nM [1].
Alogliptin has been reported to significantly reduce plasma DPP-4 activity and increase active GLP-1 levels in a dose-dependent manner in ob/ob mice. Besides, alogliptin after 4 weeks administration remarkably reduced non-fasting glycosylated hemoglobin, non-fasting plasma glucose and triglyceride levels, as well as siginificantly increased non-fasting plasma insulin and fasting pancreatic insulin content in ob/ob mice. Moreover, alogliptin treated ob/ob mice have shown the increase of early-phase insulin secretion and the decrease of plasma glucose AUC [2]
References:
[1] Feng J, Zhang Z, Wallace MB, Stafford JA, Kaldor SW, Kassel DB, Navre M, Shi L, Skene RJ, Asakawa T, Takeuchi K, Xu R, Webb DR, Gwaltney SL 2nd. Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV. J Med Chem. 2007 May 17;50(10):2297-300.
[2] Moritoh Y1, Takeuchi K, Asakawa T, Kataoka O, Odaka H. Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice. Eur J Pharmacol. 2008 Jul 7;588(2-3):325-32...
MF: C25H27N5O4
MW: 461.51
Place of Origin: Shaanxi, China (Mainland)
Type: Synthetic type 2 diabetes antagonists
Grade Standard: Medicine Grade
Brand Name: Huavet
Model Number: API-Alogliptin Benzoate
Alogliptin Purity: 99%
Usage: Pharmaceutical Intermediates
Inventory status: in stock
Shelf life: 2 years
Sample: Available
COA (Certificate Of Analysis): Available
MSDS (Material Safety Data Sheet): Available
HPLC Spectrum: Available
ISO: Approved
GC: Available
NMR (Nuclear Magnetic Resonance): Available
Packaging Details: 1g,5g,10g,50g,100g/bottle, 1kg/tin for trial order,25kg/drum for commercial quantity. Specific packing required by customer
Delivery Detail: Prompt shipme
Related Products
•Sitagliptin phosphate monohydrate
•Trelagliptin
•Vildagliptin (LAF-237)
•Linagliptin (BI-1356)
•Trelagliptin succinate
•Alogliptin (SYR-322)
