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| Name︰ | Tylosin Tartrate EP4 |
| Model No.︰ | Powder |
| Brand Name︰ | Tylos |
| Country of Origin︰ | China |
| Export Markets︰ | Europe/Asia/South America/Africa |
| Payment Details︰ | L/C,D/P,D/A,T/T |
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| Specifications︰ | TYLOAIN TARTRATE
Water Soluble Powder for oral use BPV98/EP4
Molecular Formula.(C46H77NO17)2C4H6O2
APPEARANCE:Almost White to Pale Yellow Powder
PACKING:15kg Per Fibre Drum
Tylosin A>90%,
Tylosin A+B+C+D>97%
POTENCY:Approx.900-950iu/mg
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| Advantages︰ | New Tylosin (Tartrate)
New Tylosin (Tartrate) possesses the following characteristics in quality and appearance:
(1). Composition A is above 90% (pharmacopoeia requires 80%), potency is above 900IU/mg (pharmacopoeia requires 800IU/mg), the curative effect improves completely.
(2). The content of tyramine and water is much more lower than requirements in pharmacopoeia.
(3). Unit weight is light, degree of even-mixture is high
(4). Quickly dissolved in water, high cleaning degree, not liable to be turbidity
New Tylosin (Tartrate) is the improvement of tylosin production, its quality goes far beyond the domestic level, reaching to international level and possessing marvelous quality. The new tylosin marks the quality of tylosin made in China reaching to the world level, Xi'an Hengtong Guanghua Pharmaceutical Co., Ltd. steps to the world early than others.
Pharmaceutical Features
(1) Apparent anti-mycoplasma function:
Tylosin has strong anti-activity to perineumoniae microbe (PPLO Mycoplasma )and many other kinds of mycoplasma.
(2) Wide antimacrobial spectrum: Tylosin has the activity against the gram-positive bacteria and some of the gram-negative bacteria, vibrio, and spirochete.
(3) Fast absorption and excretion: Effective concentration of Tylosin will be quickly abstained and keep stable either by injection or oral taking.
(4) Good diffusion capacity: It can permeate into all the organs,tissues,and fluid,including serous coat,blood-testis,barrier,blood barrier,blood eye barrier,so that the scope of Tylosin in clinical application is apparently enlarged.
(5) Not liable to resistance
(6) The growth promotion function: Tylosin can not only prevent disease, but also apparently promote growth, shorten breeding-period and raise FCR if it is taken continuously in small dosage.
(7) Specificity: Tylosin is a specific antibiotic for poultry and livestock; it can avoid the problems of cross infection and drug resistance by mixed usage of drugs foe human and animals.
(8) Stability: In water solution, its biological potency is stable and last 36hours.The biological potency has no apparent change after moisture absorption. Illumination makes no apparent change to its biological potency, but decrease the activity of Tylosin A. When heated, its biological potency will be lowered a little. Therefore; suggest put it in cool,dried and light-proof place.
Function and specific remedy
The high dosage Tylosin (100-500pm) is used for germicide bactericide and for treating these diseases
(1) Chicken's chronic respirator disease
(2) Chicken's necrotic enteritis
(3) Pig's asthma
(4) Bacterial pneumonia
(5) Pig's dysentery
(6) Piglet's dysentery
(7) Piglet's ileum inflammation
(8) Pet's infected atrophic rhinitis
The low dosage Tylosin (10-100ppm) is used for restrained bacterium drug ,prevent animals'disease and promote the growth of animals.
Packing:15kg Per Fibre Drum
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| Min Order︰ | 105kgs |
| Ship Date︰ | Within 10 days after confirmation purchase order |
| Standard Met︰ | Complied with EP4/BPV98 |
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TYLOSIN TARTRATE EP4 POWDE (For Injection & Oral)
TYLOSIN TARTRATE BPV2001 POWDER (For Oral Solution)
TYLOSIN TARTRATE BPV2001 GRANULAR (For Oral Solution)
Tylosin Tartrate
Synonym: Tylan Tartrate; Tylosin Tartarate
Molecular Formula.(C46H77NO17)2C4H6O2
Molecular weight:1982.31
CAS#:74610-55-2
Tylosin A>90%,
Tylosin A+B+C+D>97%
POTENCY:Approx.900-950iu/mg
Definition Tylosin Tartrate is the tartrate of tylosin. The potency per mg should not be less than 800 Units, calculated with reference to the dried substance.
Characteristics A white to pale yellow-coloured powder.
Soluble in water, freely soluble in chloroform; slightly soluble in ethanol (96%); practically insoluble in ether.
Identification
A. The infrared absorption spectrum, Appendix II A, is concordant with the reference spectrum of Tylosin tartrate.
B. The light absorption, Appendix II B, in the range 230 to 350 nm of a 0.004% w/v solution in 0.1M hydrochloric acid exhibits a maximum only at 290 nm. The absorbance at the maximum is about 0.88.
C. To 10ml of a 0.004% w/v solution in 0.1M hydrochloric acid add 1 ml of 2 M sodium hydroxide, heat on a water bath for 20 minutes and cool. The light absorbance of the resulting solution, Appendix II B, in the range 250 to 430 nm, exhibits a maximum at 332 nm.
D. Dissolve 30 mg in a mixture of 7.5 ml of pyridine, 2.5 ml of aceric anhydride and 0.15 ml of water and allow to stand. After about 10 minutes an emerald green colour is produced.
Acidity or alkalinity pH of a 2.5% w/v solution, 5.0 to 7.2, Appendix VI.
Tyramine Dissolve 50 mg in 5 ml of methanol in a 25 ml gradulated flask, add 2 ml of a 10% v/v solution of pyridine and 2 ml of a 2% w/v solution of ninhydrin. Close the flask by covering with a piece of aluminium foil and beat in a water bath at 85 of or exactly 30 minutes. Cool rapidly and add sufficient water to produce 25 ml. Use in the reference cell a solution prepared in a similar manner but omitting the substance being examined. The absorbance of the resulting solution, measured without delay, at 570 nm, Appendix II B, is not greater than that obtained by carrying out the procedure at the same time using 5 ml of a solution in methanol containing 35μg of tyramine per ml.
Composition Carries out the method for liquid chromatograghy, Appendix III D, using solutions prepared immediately before useing in a mixture of equal volume of water and acetonotrile containing (1) 0.02% w/v of tylosin BPCRS and (2) 0.02% w/v of the substance being examined.
The chromatographic procedure may be carried out using (a) a stainless steel column ( 20 cm long x 5 mm) packed with stationary phase C (5μm) ( Nucleosil C18 is suitable ), (b) as the mobile phase with a flow rate of 1 ml per minute, 0.85M sodium perchlorate in a 40% v/v solution of acetonurile the solution being adjusted to pH 2.5 using 1 M hydrochloric acid and (c) a detection wavelength of 290 nm.
The chromatogram obtained with solution (1)shows similar resolution to the sample chromatogram supplied with the tylosin BPCRS. If necessary the molarity of the sodium perchlorate may be adjusted or the temperature of the column may be raised to a maximum of 50o. The order of elution of the six major components of tylosin BPCRS in the chromatogram obtained with solution (1) is desmycinosyltylosin, tylosin C, tylosin B, tylosin D, an aldol impurity and tylosin A.
The column efficiency, determined using the peak due to tylosin A in solution (1), should be at least 22,000 theoretical plates per metre.
Loss on drying when dried at 60°at a pressure not exceeding 0.7kl’a for 3 hours, loss not more than 5.0% of its weight. Use 1 g.
sulphated ash not more than 3.0%, Appendix IX A. Use 1.67 g.
Heavy metal not more than 20ppm, Appendix IX B.
Assay Carries out a biological assay of antibiotics, Appendix XIV A. The precision of the assay is that the fiducial limit of error is not less than 95% and not more than 105% of the estimated potency. The upper fiducial limit of error is not less than 800 Units per mg, calculated with reference to the dried substance.
Action and use Antibiotic
Storage It should be kept in a well-closed container, and placed in drying places.
Preparation Tylosin tartrate soluble powder
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